POTENTIAL PROBIOTIC PROPERTIES AND IN VIVO EFFECTS OF SACCHAROMYCES CEREVISIAE CL4

Abstract

Saccharomyces cerevisiae CL4 was evaluated as a potential probiotic strain based on stress tolerance, safety-related properties, microbial interactions, and effects in rats. The strain grew at 37 °C and showed 71.0 % survival at pH 2.5 and 83.2 % survival under simulated gastric conditions. No hemolytic activity was detected. CL4 did not inhibit Candida albicans, but altered the phenotype of Pseudomonas aeruginosa, an effect also reproduced by cell-free culture fluid. In rats with metabolic syndrome, CL4 administration increased superoxide dismutase activity and affected other antioxidant defense parameters.